Levomefolate Calcium Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD (2024)


Folic acid is the man-made form of folate. Folate is a B-vitamin naturally found in some foods. It is needed to form healthy cells, especially red blood cells.Folic acid supplements may come in different forms (such as L-methylfolate, levomefolate, methyltetrahydrofolate). They are used to treat or prevent low folate levels. Low folate levels can lead to certain types of anemia. Conditions that can cause low folate levels include poor diet, pregnancy, alcoholism, liver disease, certain stomach/intestinal problems, kidney dialysis, among others. Women of childbearing age should receive adequate amounts of folic acid either through their diet or supplements to prevent infant spinal cord birth defects.

How to use L-METHYLFOLATE Calcium

Take this product by mouth with or without food as directed by your doctor, usually once daily. If you are taking the over-the-counter product, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Dosage is based on your medical condition and response to treatment. Do not increase your dose or take this product more often than directed.

Take this product regularly to get the most benefit from it. To help you remember, take it at the same time each day. Follow the diet plan recommended by your doctor or dietician. See also Notes section.

If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away.

Side Effects

Folic acid usually has very few side effects. If you have any unusual effects from taking this product, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this product, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this product do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before taking this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this product, tell your doctor or pharmacist your medical history, especially of: vitamin B-12 deficiency (pernicious anemia).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Folic acid is safe to take during pregnancy when used as directed. It is included in prenatal vitamin products. Certain spinal cord birth defects may be prevented by taking adequate amounts of folic acid during pregnancy. Consult your doctor for more details.

Folic acid passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.


Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Does L-METHYLFOLATE Calcium interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669. Symptoms of overdose may include: mental/mood changes.


Do not share this medication with others.

Lab and/or medical tests (such as complete blood count, folate blood level, vitamin B-12 blood level) should be done while you are taking this product. Keep all medical and lab appointments. Consult your doctor for more details.

Folate is naturally found in leafy green vegetables, organ meats (liver, kidney), citrus fruits, and other foods. Folic acid is added to enriched grain products such as bread, pasta, and cereal. Consult your doctor or dietician for a diet plan rich in folate/folic acid.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.


Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.



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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Levomefolate Calcium Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD (2024)


What are the side effects of L-methylfolate calcium? ›

Many people using this product do not have serious side effects. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing.

What is levomefolate calcium good for? ›

Levomefolate Calcium/ Algal Powder Capsules (15 mg-90.314 mg) are indicated for the distinct nutritional requirements of patients in need of advanced folate supplementation, specifically suboptimal L-methylfolate or maintenance-level needs, as determined by a licensed medical practitioner.

Who should not take L-methylfolate? ›

You should not use l-methylfolate if you are allergic to it. To make sure l-methylfolate is safe for you, tell your doctor if you have: seizures or epilepsy; a history of vitamin B12 deficiency or pernicious anemia; or.

What are the benefits of taking L-methylfolate? ›

L-methylfolate is a form of folate, or vitamin B9, that can help regulate serotonin and dopamine levels. Because these chemicals affect mood, some people believe taking l-methylfolate may help with depression.

What does L-methylfolate do to brain? ›

L-methylfolate helps enhance the production of 3 key neurotransmitters. This stimulated production is important because many antidepressants require a sufficient amount of neurotransmitters associated with mood.

Does L-methylfolate cause weight gain? ›

Weight gain is not a commonly reported side effect of L-methylfolate. However, individual responses to supplements can vary, and factors like diet, lifestyle, and overall health can influence weight changes.

Is levomefolate the same as methylfolate? ›

Levomefolate, also known as L-methylfolate, is the biologically active form of folic acid, vitamin B9. Levomefolate is able to cross the blood brain barrier where it is necessary for the formation of important monoamines (serotonin, norepinephrine, and dopamine).

What is the daily requirement of L-methylfolate calcium? ›

The usual adult dose is 7.5 to 15 mg daily with or without food or as directed by a licensed medical practitioner.

Does L-methylfolate help memory? ›

L-methylfolate may affect an important chemical in the brain associated with memory, and CerefolinNAC® may help in the protection of brain cells that may address cognitive health.

Should I take B12 with L-methylfolate? ›

Interactions between your drugs

No interactions were found between l-methylfolate and Vitamin B12.

Who Cannot take folate? ›

Folic acid is not suitable for some people. To make sure it's safe for you, tell your doctor before starting to take folic acid if you: have ever had an allergic reaction to folic acid or any other medicine. have low vitamin B12 levels (vitamin B12 deficiency anaemia) or pernicious anaemia.

What does MTHFR feel like? ›

Beyond heart disease, several different kinds of symptoms have been attributed to MTHFR gene mutations, including fatigue, chronic pain, brain fog, depression and anxiety, estrogen dominance, and headaches. These are common symptoms that we see and treat daily in our clinic.

What is L-methylfolate prescribed for? ›

L-methylfolate is a form of a B vitamin used to treat depression, megaloblastic anemia, and renal and hepatic impairment. L-methylfolate is available under the following different brand names: Deplin.

What does L-methylfolate calcium do? ›

L-METHYLFOLATE CALCIUM Tablets is a medical food dispensed by prescription for the clinical dietary management of the metabolic imbalances associated with depression and schizophrenia. Use under medical supervision.

How do I know if I need L-methylfolate? ›

Deficiency of folate may be asymptomatic or present with the symptoms of anemia, diarrhea, loss of appetite, and weight loss. Additional signs are weakness, sore tongue, headaches, heart palpitations, irritability, and behavioral disorders.

What is the difference between folic acid and L-methylfolate calcium? ›

Folic acid is the form of folate commonly found in processed foods, prenatal vitamins, and other dietary supplements (more on this in a bit). Methylfolate (aka L-methylfolate, 5-MTHF, 5-methyltetrahydrofolate) is a biologically active form of folate, meaning it's easy for your body to absorb.

When should I stop taking methylfolate? ›

There are also concerns that long-term use might increase certain cancers and cardiovascular disease, but the data are not robust. Nevertheless, as a prudent measure, I recommend that you consider stopping methylfolate after about one year.

Should I take methylfolate in the morning or at night? ›

Dr. Rawlins also suggests taking the dose of methylfolate in the morning and at lunchtime, as the nutrient can be somewhat energizing. Some people who take methylfolate later in the day may find it difficult to sleep at night.


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